Prostate Cancer

The NCI also continues patient enrollment in two additional Phase I clinical trials designed to evaluate the safety, tolerability and pharmacokinetics of ispinesib on an alternative dosing schedule.

One clinical trial is enrolling patients with advanced solid tumors that have failed to respond to all standard therapies and the other clinical trial is enrolling patients with acute leukemia, chronic myelogenous leukemia or advanced myelodysplastic syndromes.

Clinical Trials Status for SB-743921 SB-743921 entered a Phase I clinical trial conducted by GSK in the United States in May 2004 to evaluate its tolerability and pharmacokinetics in patients with advanced cancer.

Data relating to SB-743921 were presented at the 2005 Annual Meeting of the American Society of Clinical Oncology in May 2005.

The data presented were from 20 patients that collectively had a variety of advanced solid tumors and received doses of SB-743921 intravenously once every 21 days.

SB-743921 appears to have an acceptable tolerability profile for patients suffering from advanced solid tumors.

The dose-limiting toxicities observed to date are prolonged neutropenia, febrile neutropenia (with or without infection), elevated transaminases, hyperbilirubinemia and hyponatremia.

Notably, neurotoxicities, mucositis,...

He served as president of the NCEW in 1979 and was the first president of the NCEW Foundation, which supports NCEW programs, including an annual Minority Writers Seminar for opinion writers at newspapers and radio and television stations.

Barnard was a founding member of the First Amendment Congress, a coalition of 20 national journalism and communications organizations that sponsored national, state and local congresses on media and First Amendment topics from 1979 through 1997.

Barnard joined The Courier-Journal in 1963 as assistant managing editor.

He moved to the editorial staff as an associate editor in 1970 and became editorial page editor in 1971.

He was named associate editor of the newspaper's daily Forum page in 1988.

He began his journalism career in 1949 as a reporter at the Raleigh (N.C.) Times.

He later worked at the Winston-Salem (N.C.) Journal and the St.

Petersburg (Fla.) Times.

Barnard was born in Wayne, Pa., on Aug.

2, 1926, and grew up in Grosse Pointe Farms, Mich.

Get home delivery of the Daily Press for less than $3.33 a week.

NEWS CONTACTS Local News Editor Brad Stertz 247-7470 Columnist Tamara Dietrich...

He served as president of the NCEW in 1979 and was the first president of the NCEW Foundation, which supports NCEW programs, including an annual Minority Writers Seminar for opinion writers at newspapers and radio and television stations.

Barnard was a founding member of the First Amendment Congress, a coalition of 20 national journalism and communications organizations that sponsored national, state and local congresses on media and First Amendment topics from 1979 through 1997.

Barnard joined The Courier-Journal in 1963 as assistant managing editor.

He moved to the editorial staff as an associate editor in 1970 and became editorial page editor in 1971.

He was named associate editor of the newspaper's daily Forum page in 1988.

He began his journalism career in 1949 as a reporter at the Raleigh (N.C.) Times.

He later worked at the Winston-Salem (N.C.) Journal and the St.

Petersburg (Fla.) Times.

Barnard was born in Wayne, Pa., on Aug.

2, 1926, and grew up in Grosse Pointe Farms, Mich.

News Copyright ...