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Impact of CYP3A4 genetic variant on prostate cancer risk studied

...04, 2006 The impact of a CYP3A4 genetic variant on According to recent research published in the journal Urologic Oncology - Seminars and Original Investigations, "Genes involved in androgen metabolism are strong candidates for having an important role in the pathogenesis of CYP3A4, a protein in the cytochrome P-450 supergene family, facilitates the oxidative deactivation of testosterone." "In previous studies, patients with the G variant of a genetic polymorphism in CYP3A4 had Bangsi and colleagues, Wayne State University.

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