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Scientists identify protein linked to spread of cancer

... The findings, reported in the journal Nature, explain the puzzle of why certain cancers spread to the bones and how interfering with the process could help to prevent the spread of the disease.

Penninger added that drugs that interfere with RANKL are in development which could be used test their findings and show it the same holds true for humans.

Nearly all breast cancer tumours in women have the receptor for RANKL which Penninger said is an indirect indication that the findings are relevant to humans.

“Since there are novel inhibitors of RANKL far along in clinical development, the idea is that people who have cancer that is known to spread to bone can start taking this drug when they are diagnosed,” said D Holstead Jones, of the University of Toronto and the lead author of the study.Drugs that inhibit RANKL may also help to alleviate the severe pain that metastases can trigger and improve the quality of life of patients.

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